Meanwhile if there is occurs inhibition of the ChAT production and push down ChAT activity whether because of aging [35,36] or pathological condition such as oxidative stress, brain injury, stroke, degeneration cholinergic neuron by amyloid β peptide [7], its will directly disturb secretion of Ach and also induce decreasing amount of cholinergic neuron thus may impair memory, spatial learning and cognitive ability [37,43]. This evidence concerns the gene FGFR3 and stroke disorder.