LRRK2 and Parkinson disease: Examining the significant results reported by interrogating CMAP with our 168 DE gene disease signature, we observed that rotenone, a compound known to induce PD (31), induces a gene expression profile significantly similar to that observed within the LRRK2-G2019S cells lines (enrichment score =0.284, P = 7.6 ×10−3 and Supplementary Material, Data S2 and Fig. 3C).