Deletions of 8p have been described in 50% of IDC and 37% of lobular cancers [32] and the minimal region of loss in our study (8p23.2-23.1) includes MCPH1, a potential tumour suppressor gene [33, 34] encoding a DNA damage response protein which has also been implicated in breast cancer predisposition [35]. The gene discussed is MCPH1; the disease is breast cancer.