PAPPA and invasive breast carcinoma: For examples, PAPP-A, a factor of metabolic process, is frequently found in invasive breast cancer [26, 27]; FUS, a binding protein, is associated with neuroblastoma’s proliferation, migration and survival [28]; DLC1 is a well-known tumor suppressor for a variety of human cancers [29]; as well as IRS2 is a suppressor of cell proliferation and invasion of thyroid cancer [30].