Furthermore, using a Human Apoptosis Array Kit consisting of 35 apoptosis-related proteins (R&D) with either miR-141-overexpressing or KLF12 knockdown ovarian cancer cells, 8 out of 35 proteins (HO-2/HMOX2, ph-Rad 17, CIAP-2, survivin, HSP-70, TNFR1/TNFRSF1A, clusterin and XIAP) were upregulated (Fig. 6b). This evidence concerns the gene HMOX2 and ovarian carcinoma.