Notably, clinicopathological analysis showed that both high expression of miR-141 (>5-fold) and low expression of KLF12 (≦5-fold) were significantly correlated with late-stage cancers (P = 0.008 for high expression of miR-141 and P = 0.000 for low expression of KLF12) and metastasis (P = 0.001 for high expression of miR-141 and P = 0.01 for low expression of KLF12) (Tables 1 and 2). Here, KLF12 is linked to cancer.