PPARGC1A and obesity due to melanocortin 4 receptor deficiency: Overexpression of perilipin in adipocytes is a potential strategy for treating obesity, as PPAR-γ coactivator-1-alpha (PGC-1α) was increased in the adipose tissue of perilipin transgenic mice [22]; PGC-1α is a regulator of uncoupling protein-1, the brown adipocyte specific protein implicated in beta-oxidation attenuation.