The univariate conditional logistic regression analysis demonstrated that prior hospital stay (<6 months), urinary catheter insertion, tracheostomy, central venous catheter insertion, gastric tube insertion, urinary system disease, cephalosporins exposure, carbapenems exposure, antifungal agents exposure, glycopeptides and oxazolidinones exposure, low hemoglobin, low blood albumin, and high blood glucose were all risk factors for healthcare-acquired CREC infection. The gene discussed is ALB; the disease is urinary system disorder.