NEUROD1 and colorectal cancer: Interestingly, our β‐catenin‐binding sites included many genes activated at later stages by Wnt signaling [e.g., neurod1 (Kuwabara, Hsieh, Muotri, Yeo, Warashina, Lie, ... Gage, 2009) and 70% of β‐catenin‐bound genes of a colorectal cancer cell line (Watanabe et al., 2014)], suggesting that β‐catenin binding in early gastrulae could be a precocious event that can only act cooperatively with subsequent cooperative regulation at later stages.