However, the STING signaling pathway could adversely promote the autoimmune diseases, including systemic lupus erythematosus (SLE), lupus-like diseases, and Aicardi Goutieres syndrome (AGS), when the aberrant self-DNAs is not properly cleared out and accumulate in the cytosol under pathological conditions [22–24]. This evidence concerns the gene STING1 and systemic lupus erythematosus.