The presence of the GH receptor gene in the myocardium (to a greater extent than in many other tissues) and vessels [29], the demonstration that GH is endowed with direct vasodilating properties [30] and the prognostic role of GH circulating levels in acute HF at 1-year [31] support such GH actions independent of IGF-1 circulating levels. Here, GHR is linked to hydrops fetalis.