In addition to its association with sICAM1 levels, the ICAM1 SNP rs5498 has been shown to associate with a plethora of diseases in Asians including diabetic microvascular complications [37], proliferative diabetic retinopathy [38], oral carcinogenesis [39], migraine [40], and coronary atherosclerosis [41]. This evidence concerns the gene ICAM1 and migraine disorder.