BCR and systemic lupus erythematosus: For example, Protein Kinase C-β, encoded by the PRKCB gene, recruits IKK into lipid rafts and is involved in B-cell receptor (BCR)-mediated NF-κB activation, and the SNP rs16972959 was shown to associate with systemic lupus erythematosus (SLE) in a Han Chinese population [22].