SOCS3 and obesity due to melanocortin 4 receptor deficiency: Previous in silico methods of identifying putative epigenetically regulated obesity genes highlighted SOCS3 (suppressor of cytokine signaling 3) and RARA (retinoic acid receptor alpha) [84], both of which were identified in the FHS-LBC meta-analysis (p = 2.7 × 10−11 for cg27637521 in SOCS3 and p = 1.3 × 10−8 for cg13274938 in RARA).