For example, rs854764 is a strong eQTL for SREBF1 in both blood and adrenal tissue but in opposite directions (p = 3.8 × 10−12 and p = 4 × 10−6, respectively, in the GTEx catalog) and is associated with BMI in GIANT (p = 0.001) and waist-hip ratio (p = 9.2 × 10−4), adiponectin (p = 0.02), HbA1C (p = 0.02), type 2 diabetes (p = 0.03), triglycerides (p = 0.04), and coronary artery disease (p = 1.1 × 10−5) in GWAS results [4,7,50,52,54,57,61]. The gene discussed is ADIPOQ; the disease is type 2 diabetes mellitus.