The HR was still significant in a fully adjusted model (adjusted for age, gender, cognitive impairment, ADL impairment, sensory impairments, body mass index, depression, physical activity, cholesterol, stroke, diabetes, number of medications, and reactive C protein) that resulted in an HR of 3.23 (95% CI 1.25–8.29). The gene discussed is CRP; the disease is Cognitive impairment.