NOS3 and Stroke: In addition to lowering total-c, LDL-c and non-HDL-c levels, statins have multimodal effects mediated through enhancing endothelial nitric oxide synthase activity (with benefit on vascular integrity and function), and attenuating inflammation, and smooth muscle cell and platelet function.[41, 42] In addition to reducing vascular events, including stroke recurrence, other potential clinical effects of statins include reducing dementia, cognitive impairment and pneumonia.[23]