DRD2 and schizophrenia: DRD2 mRNA levels of all splice variants were reduced in the substantia nigra in schizophrenia compared with controls; DRD2S mRNA by 38% (F=3.05, df=55, P=0.018), DRD2L mRNA by 29% (F=3.98, df=56, P=0.051) and DRD2Longer mRNA by 22% (F=3.49, df=56, P=0.067; Figures 2a–c, respectively).