DRD2 and schizophrenia: This supports previous studies showing that treatment with antipsychotics did not change DRD2 mRNA in rodent cortex or striatum.68 Our gene expression findings are in contrast to a previous post-mortem study showing increased DRD2 receptor binding in midbrain homogenates from drug-naive and drug-treated schizophrenia cases compared with controls;31 thus, we speculate that the changes we find in DRD2 mRNA may result in less DRD2 protein in the presynaptic terminal rather than in the midbrain.