PXN and early-onset autosomal dominant Alzheimer disease: Other studies on the mechanism of neural injury towards Alzheimer disease (AD) showed that abnormal activation of FA protein units would result in massive accumulation of paxillin (widely recognized as an important component of FA) on cytoskeleton, which further caused the hyperphosphorylation of Tau and the injury of cytoskeleton, and ultimately induced nutrition disorder of neuron.