Importantly, although we identified no difference in Treg suppressive markers at day 6 p.i., the time at which Mavs−/− mice have diminished Foxp3 expression on Tregs compared to WT mice, these mice succumb starting at day 7 post-infection, thus precluding our ability to examine any downstream effects on Treg suppressive capacity in the full knockout. This evidence concerns the gene FOXP3 and infection.