APOE and early-onset autosomal dominant Alzheimer disease: These observations of a high degree of DNA sequence similarities in three separate regions (i.e., rs429358, rs7412, rs199768005) affecting the susceptibility to Alzheimer’s disease led us to define the sequence “TGGAGGACGTGCGCGGCCGCCTGG” as the “APOE4 motif” (the rs429358 nucleotide observed in APOE4 is highlighted with bold/underline).