LDHA and neoplasm: Based on previous findings, we anticipated that the two EMT-positive clones (P4B6 and P2B9) would exhibit an aggressive/stem cell phenotype, as characterised by enhanced sphere-forming ability, heightened resistance to chemotherapeutic agents, expression of stem cell markers, high ALDH activity, enhanced clonogenicity, and tumour-forming capacity in vivo1, 39, 59.