These data imply that HD antigen elicits a unique regulatory phenotype, a speculation supported by data showing that HD-DCs displayed no increases in Ym1 or Relm-α mRNA and only small increases in arginase-1 mRNA, and HD antigen actually inhibited IL-4 induction of Relm-α mRNA in DCs. The gene discussed is IL4; the disease is Huntington disease.