In mouse keratinocytes, a knockout of the the vitamin D receptor (VDR) leads to a down-regulation of tumor suppressor lncRNAs (Kcnq1ot1, lincRNA-p21, Foxn2-as, Gtl2-as, H10-as) and an increase in the expression of oncogenes (H19, HOTTIP, Nespas, mHOTAIR, Malat1 and interacting partner SRA)25, 26. The gene discussed is VDR; the disease is neoplasm.