Therefore, in the present study, we aim to explore the association of the HLA-DP polymorphisms rs3077 and rs9277535 with SLE susceptibility and further investigate the influence of HLA-DP polymorphisms rs3077 and rs9277535 on critical serum cytokine levels and clinical features in SLE in Chinese Han nationality. Here, HLA-DPB1 is linked to systemic lupus erythematosus.