And active CD4+ T cells, which could differentiate into disparate T cells subsets, play a critical role in development of SLE by secreting all kinds of cytokines, such as inflammatory cytokines (IL-1β, IL-6, INF-γ, TNF-α and IL-17), or the inhibitory cytokine IL-10. This evidence concerns the gene IL1B and systemic lupus erythematosus.