Apart from that we have revealed the significant association between the two SNPs of HLA-DP and SLE, in the present study, we also found the association between rs3077 and the lower concentration of inflammatory cytokines, as well as the lower risk of cutaneous vasculitis, which might explain partly the function of rs3077 in SLE. This evidence concerns the gene HLA-DPB1 and systemic lupus erythematosus.