PRMT1 and amyotrophic lateral sclerosis: Furthermore, arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) has been reported to regulate cellular localization of FUS, stress granule formation, and cellular toxicity of ALS-linked FUS mutants, indicating that post-translational modifications of FUS by PRMT1 affect its cellular function16, 17, 18, 19.