In this study we find that not only the concentration of OVA-IgE, IL-4, IL-5 and IL-13 which are typical markers of the Th2 immune response but also INF-gamma produced by Th1 cells in OVA-induced asthma mice were increased by administration of recombinant B7-H3, which indicated that B7-H3 may play an important role in both Th1 and Th2 cell differentiation and proliferation. The gene discussed is CD276; the disease is asthma.