The treatment with recombinant mouse B7-H3 significantly increased the IL-4 (29.34 ± 4.67 pg/mL), IL-5 (17.64 ± 0.84 pg/mL), IL-13 (421.31 ± 53.60 pg/ml) and IFN-gamma (266.01 ± 32.72 pg/ml) concentration in BALF as compared with mice in the wild-type group with asthma (P < 0.05). The gene discussed is IL5; the disease is asthma.