Notably, a substantial further accumulation of IL-4 (26.78 ± 1.19 pg/ml, 22.62 ± 1.58 pg/ml), IL-5 (10.41 ± 0.66 pg/ml, 15.30 ± 0.71 pg/ml) and IFN-gamma (150.82 ± 10.51 pg/ml, 312.62 ± 20.39 pg/ml) in plasma and BALF and OVA-IgE (132.58 ± 9.85 ng/ml) in plasma was evident in TLR2-deficient mice challenged with a combination of OVA and B7-H3 compared with the TLR2-deficient mice group with asthma (P < 0.05), data was presented in Figs 3 and 4. Here, IL4 is linked to asthma.