INS and Hypoglycemia: Night-time use of closed-loop insulin delivery significantly increased the proportion of time with glucose concentration in target range by 17·2 percentage points (95% CI 12·0–22·4, p<0·0001), reduced mean glucose concentration by 0·4 mmol/L (0·1–0·8, p=0·0211), and decreased the burden of hypoglycaemia by 89% (80–94, p<0·0001) compared with the control period.