In contrast, two patients (Patients #3 and #4) with WT BRAF exhibited no increase in LDH release in any of the treatment conditions (Figure 7B) showing that as with our previous studies in cell lines, primary tumor samples with WT BRAF display no significant sensitivity to autophagy inhibition (Levy et al., 2014; Levy and Thorburn, 2012). The gene discussed is BRAF; the disease is neoplasm.