INS and type 2 diabetes mellitus: Moreover, this lipid accumulation was reversible with the use of insulin-sensitizing and secretagogue therapy, provided in the form of the biguanide metformin and the sulfonylurea glipizide, consistent with a direct link between systemic insulin resistance and the accumulation of hepatic lipid, as has been demonstrated in human patients with type 2 diabetes (Mazza et al., 2012; Taylor, 2013).