Previously, it was reported that guinea pigs were largely insensitive to the cytotoxic effects of STZ or of alloxan, an alternative GLUT2-dependent β-cell toxin, when administered systemically; however, administration directly into the pancreatic circulation yielded uniform hyperglycemia from alloxan, and isolated guinea-pig β cells are susceptible to ex vivo STZ treatment (Lenzen, 2007, 2008). The gene discussed is SLC2A2; the disease is Hyperglycemia.