WNT3A and melanoma: In murine myoblasts, WNT3A/β-catenin signaling has previously been shown to increase mitochondrial biogenesis,54 therefore it is reasonable to presume that the mitochondrial effects noted in PTENWT melanoma cells in response to hyperactive WNT/β-catenin signaling (Figures 4 and 5), could be due to alterations in mitochondrial numbers in these cells.