For example, a number of key glycolysis enzymes exhibit reduced binding to β-catenin in the presence of WNT3A ligand stimulation (including glyceraldehyde-3-phosphate dehydrogenase, lactate dehydrogenase, phosphofructokinase-1 and glucose-6-phosphate isomerase; Supplementary Table S4), which suggests that upon WNT/β-catenin signaling in PTENWT melanoma cells, β-catenin no longer binds to glycolysis enzymes, which may lead to metabolic reprogramming events such as reduced glycolytic capacity. The gene discussed is WNT3A; the disease is melanoma.