Further investigations demonstrated that autophagy markers are markedly reduced in PTENWT melanoma cells in response to hyperactive WNT3A signaling (Figure 7h), but not in PTENMut cells (Supplementary Figure 7g) suggesting that autophagy (and thus the mitophagy process), is impaired in PTENWT melanoma cells in response to WNT/β-catenin signaling. The gene discussed is WNT3A; the disease is melanoma.