OPA1 and melanoma: As increased expression of mitochondrial fusion proteins MFN1, MFN2 and OPA1 would explain why mitochondrial networks are increased in PTENWT melanoma cells, we verified their increased expression in response to WNT/β-catenin signaling by immunofluorescence (Supplementary Figure 7b) and flow cytometry (Supplementary Figure 7c) to further corroborate our findings.