WNT3A and melanoma: It is well known that the WNT/β-catenin pathway is associated with deregulated cell proliferation and neoplasia through multiple mechanisms including cell cycle control, regulation of apoptosis and mitotic control, as previously reviewed.34 To investigate the role of the WNT/β-catenin pathway in melanoma cells, we first analyzed long-term cell proliferation in response to forced WNT3A signaling.