APC and neoplasm: For example, in colorectal cancer loss-of-function mutations in APC can be detected in up to 80% of tumors,9, 10 leading to increased β-catenin signaling and prompting researchers to develop inhibitory compounds for the pathway.11 However, it is not that simple in all tumor contexts, as high levels of nuclear β-catenin does not always correlate with poor prognosis for all tumor types, including medulloblastoma,12 ovarian cancer,13 prostate cancer14 and melanoma.15