We have previously reviewed the critical role WNT signaling has in cancer cell metabolism,25 so our current finding that WNT/β-catenin signaling imparts altered metabolic profiles in melanoma cells dependent on PTEN expression levels, demonstrates that cross-talk between the PI3K-AKT and WNT/β-catenin pathways exists to induce metabolic reprogramming in tumor cells. Here, PTEN is linked to neoplasm.