PRKN and melanoma: We investigated PINK1-Parkin accumulation in PTENWT melanoma cells in response to WNT/β-catenin signaling to determine whether impairment of either could lead to increased levels of MFN proteins and found that while differences in Parkin levels were modest (slightly increased in response to WNT3A signaling; Figure 7g and Supplementary Figure 7e; which fits with the recent finding that WNT3A increases endogenous Parkin in glioblastoma cells57), we did detected a marked difference in PINK1 expression (Figure 7g).