However, we cannot rule out that another autophagy regulator is also involved, given that p62 accumulation itself is also a marker of autophagy.95 Interestingly, DKK3 (a WNT/β-catenin signaling regulator) was recently found to be a marker of autophagy in melanoma, suggesting that inhibition of WNT/β-catenin signaling could increase autophagy in melanoma cells.96 This evidence concerns the gene SQSTM1 and melanoma.