Indeed, β-catenin signaling has been shown to increase or repress melanoma cell invasion depending on the cell line tested.18, 42 Here we provide evidence that a reduction in PTEN expression in melanoma cells markedly alters their phenotypic response to WNT/β-catenin signaling by reprogramming distinct metabolic signatures, which is underpinned by changes in mitochondrial activity in PTENWT, but not in PTENMut cells. Here, PTEN is linked to melanoma.