WNT/β-catenin signaling has previously been found to be a negative regulator of autophagy, by repressing p62 (encoded by SQSTM1) expression, which is a protein that targets cargos for autophagy.59 Importantly, we also detect repression of SQSTM1 expression in PTENWT melanoma cells following treatment with rWNT3A (Figure 7j). The gene discussed is SQSTM1; the disease is melanoma.