WNT3A and cancer: In addition to the effects on tumor growth, WNT signaling pathways are also regulators of cell motility, able to enhance or inhibit the migratory capacity of cancer cells in a cell-type-specific manner.35, 36, 37, 38, 39, 40, 41 Using the two WNT3A overexpression lines (Figure 1e), we evaluated the cells' ability to fill a wound scratch and found an inverse correlation in cell migration in response to high WNT/β-catenin signaling between the two lines (Figure 2a and Supplementary Figure 2a).