WNT3A and melanoma: It is now known that adaptations of bioenergetic activity and mitochondrial-derived ATP production, results in the remodeling of mitochondrial morphology, as previously reviewed.48 Given the metabolic-induced effects of WNT3A in melanoma cells (Figure 3), we decided to investigate mitochondrial architecture in these cells using the cell-permeant, MitoTracker mitochondrion-selective probe (Invitrogen, Life Technologies Ltd, Paisley, UK).