PINK1 undergoes voltage-dependent proteolysis in healthy mitochondria, but is stabilized in a full-length (FL) form on the OMM of damaged mitochondria,58 where we found that WNT3A increased FL-PINK1 expression (Figure 7g), suggesting that PTENWT melanoma cells harbor defective mitochondria in response to WNT/β-catenin signaling that are tagged for selective autophagy (mitophagy). This evidence concerns the gene PINK1 and melanoma.