FBP2 and colorectal cancer: DNA methylation mediates silence of fructose-1,6-bisphosphatase 1 (FBP1) and fructose-1,6-bisphosphatase 2 (FBP2) via promoter methylation in breast, gastric, liver and colorectal cancers.120, 121, 122, 123 FBP1 and FBP2 are rate limiting enzymes for gluconeogenesis that antagonize glycolysis, and their decreased expression promotes glycolytic flux for driving macromolecules biosynthesis and ATP production.