As an example, the re-expression of miR-143, which targets hexokinase II 3′-untranslated region, overturned the glycolytic phenotype and inhibited cancer growth.154 On the contrary, oncogenic miRNAs that target LKB1/AMPK or PTEN tumor suppressive pathways may represent attractive targets for the design of therapeutic anti-miRNAs. This evidence concerns the gene STK11 and neoplasm.