For instance, anti-miR-21-mediated inhibition (which targets PTEN tumor suppressor), restored PTEN expression in hepatocellular cancer and contributed to treatment.209 One major challenge facing miRNA-targeting focuses on the safe and efficient delivery of miRNA mimics and anti-miRNAs.210 Advances in delivery technology will accelerate realization of miRNA-based therapeutics in the clinical practice. Here, PTEN is linked to hepatocellular carcinoma.