NNMT is overexpressed in a variety of cancers, including lung, liver, kidney bladder and colon cancers and exerts an oncogenic effect.50, 51, 52, 53 Recently, NNMT expression was found to be upregulated in human embryonic stem cells, and NNMT is indispensable for the maintenance for pluripotency. The gene discussed is NNMT; the disease is cancer.