Consistent with its tumor suppressive role, frequent deletions in SIRT6 have been detected in cancer cell lines and colon, pancreatic and hepatocellular cancers.143 SIRT7 is another sirtuin that directly interacts with MYC.144, 145 SIRT7 possesses selective catalytic activity towards H3K18Ac. Here, SIRT6 is linked to neoplasm.