Moreover, paraganglioma patients with SDH or FH-deficiency associated DNA CIMP had a much worse prognosis compared with other molecular subtypes, indicating that epigenetic dysregulation in SDH or FH-mutant patients contributes to tumor development and progression.89 Thus, genetic mutations in FH and SDH can lead to accumulation of fumarate and succinate, respectively, which drives tumorigenesis via epigenetic deregulation. The gene discussed is FH; the disease is paraganglioma.