PBRM1 and nonpapillary renal cell carcinoma: BAF180 KO/HIF1A cDNA 786-O cells exhibited increased cell survival/proliferation, compared with BAF180 WT/HIF1A cDNA 786-O cells (Figures 4b and c), demonstrating that loss of the tumor-suppressive activity of BAF180 in H2 ccRCC cells is due to the loss of HIF1A gene expression.