PBRM1 and nonpapillary renal cell carcinoma: To test if BAF180 tumor-suppressive function in H1H2 ccRCC cell lines depends on HIF1A expression, we generated SLR25/Tet-on BAF180/HIF1A KD cells; to test if BAF180's tumor-promoting activity is associated with HIF2A expression, we also generated SLR25/Tet-on BAF180/HIF2A KD cells, along with SLR25/Tet-on BAF180/SCR shRNA cells as a control (Figure 4d).