PBRM1 and nonpapillary renal cell carcinoma: Re-expression of PBRM1 in BAF180-deficient ccRCC cell lines, both in stable or inducible manner (Figure 2), reduce ccRCC proliferation/survival, further confirming that BAF180 is a tumor-suppressive protein in the BAF180-deficient ccRCC cell lines, which is consistent with published papers.7, 28, 29