In fact, multiple publications reported that BAF180 is required for p53 to activate p21 expression under condition of p53 activation.29, 44, 45 Although p53 can be activated in ccRCC,29 it is unlikely that p53 is activated in ccRCC cells under our study condition that cells are cultured under normoxia. Here, PBRM1 is linked to nonpapillary renal cell carcinoma.