Thus, the goal of this study was to determine if PBRM1/BAF180 is important for HIF1- and HIF2-mediated transcriptional response, and if the BAF180 gene mutation is associated with HIF1A retention in H1H2 ccRCC, a tumor-suppressive factor in established ccRCC tumors. Here, PBRM1 is linked to nonpapillary renal cell carcinoma.