SMARCA1 and neoplasm: Our laboratory has previously demonstrated that the BAF180-containing SWI/SNF chromatin remodeling complex, PBAF complex, acts as a co-activator for HIF1- and HIF2-mediated transcriptional responses by remodeling the promoters of HIF target genes.23 These data support a hypothesis that the PBRM1 gene product, BAF180, a unique component of the PBAF complex, may also be important for the HIF-mediated hypoxia response and PBRM1/BAF180 gene mutation may reduce the tumor-suppressive activity of HIF1 in H1H2 ccRCCs.