PBRM1 and cancer: Mutations in the BAF180 gene or downregulation of BAF180 gene expression has been observed in various cancer types, including ccRCC, suggesting a tumor-suppressor function.7, 10, 11, 38, 39, 40, 41, 42 Our data confirmed that BAF180 is mutated in a subset of ccRCC cell lines (Figure 1a and Supplementary Figure 2a) and primary tumors (Figure 1b and not shown).