WRN and neoplasm: To determine whether this result was a common feature of cells in a CD44+/CD24− state, we then measured the expression of BLM, BRCA2, FANCF, NBN, PMS1, RAD50, RDM1, WRN, ATM and ATR (i) in the tumor-derived cell lines utilized in our functional genomic screen (Figure 2C and Figure 2—figure supplement 2), (ii) in FACS-sorted H1650, A549 and MCF7 cells (Figure 2D and Figure 2—figure supplement 3A) and (iii) in four FACS-sorted primary human NSCLC tumors (Figure 2E and Figure 2—figure supplement 3C).