CD44 and neoplasm: Therefore, to determine whether the selective vulnerabilities that we identified in our screen also typified stochastically generated CD44+/CD24− cells, we extended our analysis to four pairs of tumor-derived (CD44+/CD24−)lo cell lines that were FACS-sorted on the basis of their surface expression of CD44 and CD24 (Figure 1C and Figure 1—figure supplement 3).