As shown in Fig. 2a, LUAD samples carrying three types of PTVs exhibited statistically significant reductions in mRNA expression compared to samples lacking RBM10 mutations or CNAs (P = 2.2e-06, 0.00011, 0.0013 for nonsense, frameshift, and splice site mutations, respectively), or tumor-adjacent normal tissues (P = 0.00035, 0.00035, 0.029 for nonsense, frameshift, and splice site mutations, respectively). The gene discussed is RBM10; the disease is neoplasm.