The main findings of the present study are the following: (1) Decreased myocardial and serum miR-19b expression is present in AS patients, namely in those with HF; (2) Both myocardial and serum miR-19b are inversely associated with myocardial LOX protein and CCL, as well as with LV stiffness in AS patients; (3) miR-19b inhibition increased the expression of CTGF and LOX protein in human adult fibroblasts. The gene discussed is CCN2; the disease is hydrops fetalis.