Unlike in FSGS, expression of sphingomyelinase-like phosphodiesterase 3b (SMPDL3b) is high in diabetic nephropathy, shifting suPAR mediated podocyte injury from a migratory (FSGS) to an apoptotic phenotype (diabetic nephropathy)21. Here, SMPDL3B is linked to focal segmental glomerulosclerosis.