GPT and chronic myelogenous leukemia, BCR-ABL1 positive: Across second and third/fourth-line CP-CML and advanced leukemia cohorts in the 4-year/3-year update of the phase I/II study, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) elevation TEAEs occurred in 17% and 14% of patients, respectively, with grade 3/4 ALT and AST TEAEs occurring in 7% and 3% of patients, respectively (Kantarjian et al., 2014).