Next, to evaluate the cytotoxic effect of CD38-specific T cells against four AML cell lines, THP-1 and CMK cells highly expressing CD38 (>99% CD38 expression rate), HL60 cells partially expressing CD38 (35.05%) and HEL cells without CD38 expression, the lactate dehydrogenase (LDH) releasing assay was performed. Here, CD38 is linked to acute myeloid leukemia.