CD38 and acute myeloid leukemia: After human T cells transduced with anti-CD38-CAR as an effector (E) were cultured with the respective AML cell line as a target (T) at an E:T ratio of 1:2 for 3 days, the LDH assay showed efficient and specific cell lysis against THP-1 cells and CMK cells by T cells bearing anti-CD38-CAR, but no impact on specific cytotoxicity against HEL cells.