As shown in Figure 5 and Table 1, CD38 expression was enhanced by ATRA in AML cells from patients along with AML cell lines, and the 3-day incubation of transduced T cells bearing the anti-CD38-CAR abrogated AML cells from patients' AML cells by the enhancement of CD38 induced by ATRA (Figure 5 and Table 1). The gene discussed is CD38; the disease is acute myeloid leukemia.