TARDBP and amyotrophic lateral sclerosis: Additional mutations in over twenty genes, among which the most frequent C9ORF72, TAR DNA binding protein 43 (TARDPB), and fused in sarcoma (FUS), have been associated with familial forms of ALS and account for about 10–15% of all ALS cases, providing insights into the complex genetic mechanisms that lead to motor neuron death [6].