In previous work, we have compared miRNAs transcriptional profiling of nontransgenic and ALS microglia under resting conditions and after inflammatory activation induced by extracellular ATP through P2X7 receptor, by identifying the upregulation of immune-enriched miR-22, miR-155, miR-125b, and miR-146b in ALS microglia. Here, P2RX7 is linked to amyotrophic lateral sclerosis.