We transfected β-TrCP1, FBXW2 (wt versus mutant) and SKP2 alone or in various combinations into lung cancer cells (Fig. 5b and Supplementary Fig. 5d) and found that transfection of β-TrCP1 alone stimulated the monolayer growth and increased clonogenic survival of lung cancer cells. The gene discussed is BTRC; the disease is lung cancer.