Given the overall patient survival data are available from these 102 tumour samples58, we next correlated patient overall survival with expression of these three F-box proteins and found that expression of β-TrCP1 and SKP2 was positively, whereas expression of FBXW2 was negatively, associated with poor survival of lung cancer patients (Fig. 6d–f). Here, FBXW2 is linked to lung cancer.