Furthermore, among 102 tumour TMA samples, the high FBXW2 staining group is largely associated with low staining group of β-TrCP1 (P<0.001, r=−0.392, Pearson's χ2-test) and SKP2 (P<0.001, r=−0.478, Pearson's χ2-test), whereas the low FBXW2 staining group is associated with high staining group of β-TrCP1 and SKP2 (Fig. 6b,c), respectively, further supporting a relationship in which FBXW2 is targeted by β-TrCP1, whereas SKP2 is targeted by FBXW2. This evidence concerns the gene SKP2 and neoplasm.