Finally, immunohistochemical staining of tumour tissues revealed that E269K-expressing tumour had increased proliferation index (increased Ki-67 and decreased p21), reduced apoptosis index (cleavage caspase-3) and increased SKP2 expression, whereas wild-type FBXW2 had just an opposite effect (Fig. 7h). The gene discussed is CASP3; the disease is neoplasm.