Among eight lung cancer cell lines and one immortalized line (BEAS-2B) tested, there is a general tendency of inversed protein levels between β-TrCP1 and FBXW2, as well as between FBXW2 and SKP2 (Fig. 6a), whereas the mRNA levels among them are similar in all lines (Supplementary Fig. 6a). Here, BTRC is linked to lung carcinoma.