We found that epithelial cell damage and lung inflammation (Fig. 5a), levels of cytokines and IgE (Fig. 5b), MC and ILC2 expansion (Fig. 5c) were all attenuated or decreased in condition of CFTR deficiency in epithelial cells but CFTR sufficient myeloid cells, a finding suggesting that myeloid, and perhaps lymphoid, deficiency could contribute to the activation of the inflammatory circuit in CF. The gene discussed is CFTR; the disease is cystic fibrosis.