Several previous studies have reported dominant variants in TBK1 in cases of MND, FTD, and MND-FTD, accounting for approximately 1% of all cases (Borghero et al., 2016, Cirulli et al., 2015, Exome Aggregation Consortium (ExAC), Freischmidt et al., 2015, Gijselinck et al., 2015, Le Ber et al., 2015, Pottier et al., 2015, Shu et al., 2016, Tsai et al., 2016, van Rheenen et al., 2016, Williams et al., 2015). This evidence concerns the gene TBK1 and mild neurocognitive disorder.