Although the incidence of MND-associated variants specifically in the Scottish population is unknown, screening of an unselected Scottish cohort for variants in SOD1 identified a high frequency of the I114T variant, which was found in 9% cases (Jones et al., 1995), and more recently C9orf72 expansions were found in 11% of Scottish cases (Cleary et al., 2016). Here, SOD1 is linked to mild neurocognitive disorder.