Two genes, TBK1 and NEK1, have recently been associated with MND, with each thought to account for a small proportion of cases, although they have not been screened in the Scottish MND population (Brenner et al., 2016, Cirulli et al., 2015, Freischmidt et al., 2015, Kenna et al., 2016). This evidence concerns the gene TBK1 and mild neurocognitive disorder.