MAPK3 and neoplasm: Conventional MAPKs mainly divided into four major groups: the extracellular signal-regulated kinase 1 and 2 (ERK1/2), the c-Jun N-terminal kinases 1–3 (JNK1-3), the p38 isoforms (p38α, β, γ, and δ) and ERK5, which are involved in tumor progression and metastasis [16].