EPCAM and neoplasm: As shown in Figure 4B, the bioluminescence intensities, which are indicative of tumor burdens, in the PBS and mGFP CAR groups progressively increased from day 8 to day 43, demonstrating a rapid tumor progression after SKOV3-Luc inoculation, whereas the bioluminescence intensities in the anti-EpCAM CAR group quickly decreased after the treatment and remained low in most of the treated mice for at least 43 days.