The results of IHC staining showed that GPRC5A level is significantly decreased in NSCLC compared to adjacent normal tissues (Figure 5A), ceruloplamsin (Cp) level is significantly increased in NSCLC tissues (T) compared to adjacent normal tissues (N) (Figure 5B), perioston (POSTN) and lipocalin 2 (LCN2) were significantly increased in NSCLC tissues compared to normal lung tissues (Figure 6A–6B). The gene discussed is LCN2; the disease is non-small cell lung carcinoma.