By immunoblot, Q-PCR, and immunohistochemical (IHC) staining, we found that ceruloplasmin, lipocalin-2, and periostin are not only upregulated in the lung tumor tissues of Gprc5a-ko mice, but also in human non-small cell lung cancer (NSCLC). Here, GPRC5A is linked to non-small cell lung carcinoma.