The immunity-related proteins Mib1, RhoB and Gbp5 became more abundant in macrophage lysosomes after treating with L. m, HSV-1 or VSV, while lysosomal Oasl2 (Viperin) was augmented by both virus infections (Figure 6A left panel, 6B-6F). This evidence concerns the gene GBP5 and viral infectious disease.