ASB3 and colorectal carcinoma: To further elucidate the effects of ASB3 on the oncogenesis and progression of CRC, HCT116 cells stably overexpressing ASB3 cDNA or its mutants (1 × 106 cells each mouse) were subcutaneously or intrasplenically injected into nude mice, and the tumorigenicity and hepatic metastasis were investigated.