Activated glia are known to contribute to neuropathic pain by releasing pro-inflammatory cytokines such as IL-1β and TNF-α [13–15], and suppressing the activation of astrocytes and microglia down-regulated the expression of pro-inflammatory cytokines, which led to the alleviation of nerve injury-induced neuropathic pain [40, 41]. This evidence concerns the gene IL1B and neuropathic pain.