LMNA and mandibuloacral dysplasia: This finding is especially intriguing given that lamin A/C are linked to several diseases, including the cardiomyopathy, muscular dystrophy, and peripheral neuropathy that characterize and cause death in the lmna (−/−) mice before 2 months of age [39, 44], as well as Hutchison-Gilford progeria syndrome, adult-onset partial lipodystrophy, and mandibuloacral dysplasia [47, 48].