In colorectal, liver and pancreatic cancer [38, 39] and in a subset of tumors like MM, Deptor mainly acts as a tumor suppressor, since its loss promotes growth and survival by activating Akt/mTOR signaling, resulting in phosphorylation of SGK1 (Serum and Glucocorticoid regulated Kinase 1) and of its substrate NDRG1 (N-Myc Downstream Regulated 1) [40, 41]. Here, NDRG1 is linked to familial pancreatic carcinoma.