SLC5A2 and diabetes mellitus: In this regard, pharmacologic inhibitors of the renal sodium–glucose cotransporter 2 (SGLT2) are emerging as a novel group of drugs that lower blood glucose and HbA1c levels and improve whole body insulin sensitivity in animals and humans with diabetes, largely by blocking renal proximal tubular reabsorption of glucose which increases urinary glucose excretion (glycosuria) [13, 14].