Several interferon-inducible genes involved in anti-viral immune responses, including the ubiquitin-like protein modifiers ISG12-1 and ISG20L2, tripartite motif proteins TRIM8, TRIM23, TRIM24, and TRIM29, and ubiquitin-specific peptidases USP22, USP32, and USP49, were also differentially regulated in response to vvIBDV infection. Here, USP49 is linked to infection.