SLC7A11 and myeloid sarcoma: We here sought to shed light on this controversial subject and clarify the potential of system xc− as a drug target in the treatment of MS, by investigating xCT protein expression levels in NAWM of MS patients as well as the CNS and spleen of EAE-induced mice and by exploring whether EAE development is affected by xCT deletion using xCT knockout (xCT−/−) mice with a C57BL/6J background [46] or bone marrow (BM) chimeras thereof.