Semi-quantitative Western blotting served to study protein expression of xCT, the specific subunit of system xc−, as well as of regulators of xCT transcription, in the normal appearing white matter (NAWM) of MS patients and in the CNS and spleen of mice exposed to experimental autoimmune encephalomyelitis (EAE), an accepted mouse model of MS. Here, SLC7A11 is linked to experimental autoimmune encephalomyelitis.